Viagra may be the most familiar oral treatment for erectile dysfunction (ED.. in other words impotence). That’s probably because it was the first on the market and created a stir when it was promoted by the Brazilian 1960s-70s football star Pele, and by Senator Bob Dole. Viagra (with its active ingredient sildenafil) was approved for prescription in the US on March 27 1998. Two other treatments for ED followed: Levitra (vardenafil) on August 19, 2003, and Cialis (tadalafil) on November 21, 2003.
Cialis was created by Glaxo Wellcome (now GlaxoSmithKline) under a partnership between Glaxo and ICOS to develop new drugs that began as long ago as August 1991.
In May 2002, it was reported to the American Urological Association that clinical trial testing demonstrated that tadalafil was effective for up to 36 hours after being taken. That was novel. Viagra reportedly lasts 4-5 hours only. Cialis is measured in terms of “half-life”. This is one of the major advantages of Cialis has over Viagra and Levitra. Because there is a restriction on taking no more than one pill (of Viagra, sildenafil, Levitra or Cialis) in any 24 hour continuous period, then more than one sexual session of four hours within 24, was not possible with Levitra or Viagra. However with Cialis, once taken, there’s up to 36 hours to engage in sexual activity, giving more freedom to decide when and where to have sex, and make it less necessary to plan exactly when to take the pill and have sex. Cialis is often known as the Weekender Pill, because if taken on a Friday evening, many men have reported that its effects can still be experienced on the Saturday and well into Sunday. That freedom to have sex within a much longer corridor of time means than you can go with the flow- be more romantic, and not have to plan everything around sexual activity, which can make it seem mechanical and not spontaneous.
Cialis’ active component is tadalafil. This component functions as an inhibitor of the PDE5 enzyme and allows blood to enter the penis more freely, and then not be attacked by the PDE5 which eats away at the erection. In other words tadalafil allows for erections to be achieved when there is physical stimulation, and for the erection to be sustained for longer. That longer duration will normally allow full and fulfilling sexual engagement to take place.
The stronger doses of the Cialis pill (20mg) should not be prescribed for men with underlying health conditions like high blood sugar, cardiovascular (heart) diseases, high blood pressure and renal (kidney) dysfunction. In fact it is always best to start off with a low dose, and see if that does the trick. If not gradually increasing the dose of the pill (but not taking more than a single pill in any 24 hour period).
Cialis, like all the other oral ED treatments, is only available on prescription. You will need to go through your complete medical history with your doctor (or online medical practitioner) to make sure it is safe to take it. You will also be warned that if you experience any adverse effects after taking it, you should cease to use it, and report back for further advice. If after taking the medication the effects seem quite acute- you feel dizzy, nauseous, a tingling sensation in the chest or numbness in the hands, legs or any other part of your body, you should first call for medical assistance immediately, and later tell your doctor of this.
However it should be emphasised that these side effects in healthy men are unlikely to occur. Many users of Cialis experience no side effects or ones that are so mild, they can be easily tolerated.